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To many Americans, there is only one caliber for a personal defense handgun and that's the .45 auto. Glock acknowledged that sentiment with the development of the Glock 21. To those who believe that personal defense starts with the numbers "4" and "5" (and in that order) the Glock Model 21 has been the answer to their prayers. This short-frame double-action-only pistol holds 13-rounds of .45 ACP ammunition and features fixed 3-dot sights and a picatinny rail.